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#neuraminidases

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Giuseppe Michieli<p>Increase of <a href="https://mstdn.science/tags/Synergistic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Synergistic</span></a> Secondary <a href="https://mstdn.science/tags/Antiviral" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Antiviral</span></a> <a href="https://mstdn.science/tags/Mutations" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Mutations</span></a> in the <a href="https://mstdn.science/tags/Evolution" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Evolution</span></a> of <a href="https://mstdn.science/tags/H1N1pdm09" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>H1N1pdm09</span></a> <a href="https://mstdn.science/tags/Influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Influenza</span></a> Virus <a href="https://mstdn.science/tags/Neuraminidases" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Neuraminidases</span></a>, Vaccines: <a href="https://www.mdpi.com/1999-4915/16/7/1109" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="">mdpi.com/1999-4915/16/7/1109</span><span class="invisible"></span></a> </p><p>The data indicate a slight increase in viral NA bearing two additional potentially synergistic substitutions, NA-I223V and NA-S247N, in the 2023–2024 season, which both result in a slight reduction in susceptibility to NA inhibitors.</p>
Giuseppe Michieli<p>A(<a href="https://mstdn.science/tags/H2N2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>H2N2</span></a>) and A(<a href="https://mstdn.science/tags/H3N2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>H3N2</span></a>) <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>influenza</span></a> <a href="https://mstdn.science/tags/pandemics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>pandemics</span></a> elicited durable cross-reactive and protective <a href="https://mstdn.science/tags/antibodies" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>antibodies</span></a> against avian <a href="https://mstdn.science/tags/N2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>N2</span></a> <a href="https://mstdn.science/tags/neuraminidases" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>neuraminidases</span></a>, Nat Commun.: <a href="https://www.nature.com/articles/s41467-024-49884-9" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41467-024</span><span class="invisible">-49884-9</span></a> </p><p>The anti-AIV N2 antibodies titers correlate with antibody titers to the 1957 N2, suggesting that <a href="https://mstdn.science/tags/exposure" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>exposure</span></a> to the A(H2N2) virus contribute to this reactivity. These findings underscore the critical role of neuraminidase <a href="https://mstdn.science/tags/immunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunity</span></a> in <a href="https://mstdn.science/tags/zoonotic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>zoonotic</span></a> and pandemic influenza <a href="https://mstdn.science/tags/risk" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>risk</span></a> <a href="https://mstdn.science/tags/assessment" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>assessment</span></a>.</p>
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