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#gaht

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Hey lovelies 🩷

If you're currently asking yourself whether it's "worth" starting gender-affirming hormone therapy (GAHT) and/or transitioning, please ask yourself the following instead:

  • "Do I want to take GAHT?"
  • "Do I want to transition?"
  • "Do I think I might be, know that I am, or want to be a different gender to the one I was assigned at birth?"

This are key questions to ask yourself, and it's never too late to start asking them.

Worrying about whether or not you will eventually pass as cis is something that sadly delays or stops many of us from starting GAHT and/or transitioning.

Please don't let yourself fall into the same mental trap that many of us have fallen into 🥺

You don't need to pass as cis to:

  • Be attractive.
  • Be loved.
  • Be happier about how you look, sound, and feel.
  • Justify taking GAHT and/or transitioning.

Small study, but interesting.

Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals

bmcmedicine.biomedcentral.com/

#trans #transgender #GAHT #HRT

@Impossible_PhD I thought you might be interested. I don't really know what to make of this.

BioMed CentralGender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals - BMC MedicineBackground Limited data exists regarding gender-specific microbial alterations during gender-affirming hormonal therapy (GAHT) in transgender individuals. This study aimed to investigate the nuanced impact of sex steroids on gut microbiota taxonomy and function, addressing this gap. We prospectively analyzed gut metagenome changes associated with 12 weeks of GAHT in trans women and trans men, examining both taxonomic and functional shifts. Methods Thirty-six transgender individuals (17 trans women, 19 trans men) provided pre- and post-GAHT stool samples. Shotgun metagenomic sequencing was used to assess the changes in gut microbiota structure and potential function following GAHT. Results While alpha and beta diversity remained unchanged during transition, specific species, including Parabacteroides goldsteinii and Escherichia coli, exhibited significant abundance shifts aligned with affirmed gender. Overall functional metagenome analysis showed a statistically significant effect of gender and transition (R2 = 4.1%, P = 0.0115), emphasizing transitions aligned with affirmed gender, particularly in fatty acid-related metabolism. Conclusions This study provides compelling evidence of distinct taxonomic and functional profiles in the gut microbiota between trans men and women. GAHT induces androgenization in trans men and feminization in trans women, potentially impacting physiological and health-related outcomes. Trial registration Clinicaltrials.gov NCT02185274.

We realised that we're rapidly approaching the 1000 day milestone on feminising gender-affirming hormone therapy, so we went ahead and checked the exact date.

Day 1000 will be Friday 26th July 2024 😊

More importantly perhaps, day 1001 will be Saturday 27th July 2024... which just so happens to be London Trans+ Pride 😲 :TransHeart:

Gives us an reason to be looking forward to it this year 🥰

#LondonTransPride #LondonTransPride2024 #Pride #Pride2024 #PrideSeason #trans #transgender #TransFem #GAHT #HRT #queer #LGBTQ+ #LGBTQIA+

Replied in thread

@yourautisticlife

Thanks. I'm not on any heart medication as such. I was on metoprolol for maybe a year because a doctor refused to believe me that the BP he was seeing was "white coat syndrome." I changed doctors and stopped that probably 10 years ago now.

I have been taking a diuretic as part of my #GAHT for almost 13 years, but this is a relatively new development.

I am on a blood thinner, but that shouldn't affect heart rate.

PSA for any trans person getting feminising gender-affirming hormone therapy through the NHS

Most NHS gender clinics across the UK have heavily restrictive oestradiol (estradiol; E2) target ranges, which are not in line with international best practice or guidance 😮‍💨

Some target as low as 200 to 400 pmol/L (54 to 109 pg/mL).

Many target an arbitrary, narrow 400 to 600 pmol/L (109 to 163 pg/mL) range.

Only a couple are more in line with international guidance, using a wider 350 to 750 pmol/L (95 pg/mL to 204 pg/mL).

If you test above their range, they will typically reduce your E2 dose, even if you feel better with a higher E2 level.

As such, it is always morally justified to take steps to make your E2 level lower when they demand a blood test to stop your dose being lowered :TransHeart: ✊

Edit: This post about E2 ranges from NHS GICs is from 2021, but given how glacially the NHS moves, it's probably still accurate.