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#h5n1 #avianflu #birdflu #vogelgrippe ##Geflügelpest #doku #video #pandemie #viren #spillover

"Es gab und gibt aber auch immer wieder schwere Krankheits- und Todesfälle nach einer H5N1-Infektion. Die Furcht, das Influenza-Virus H5N1 könnte zum Auslöser einer Pandemie wie der Spanischen Grippe 1917 oder der sogenannten Asiatischen Grippe 1957 werden, liegt also nahe."

Dokumentarfilm: Spillover · Planet der Viren

br.de/nachrichten/wissen/vogel

BR24 · Vogelgrippe H5N1: Wie groß ist die Gefahr einer Pandemie?By Jan-Claudius Hanika

Die Umstellung auf pflanzenbasierte Gerichte im wachsenden Markt für Essenspaket-Lieferungen könnte den Treibhausgas-Fußabdruck des Sektors deutlich reduzieren. Viele Verbraucher entscheiden sich jedoch bei der Online-Bestellung von Lebensmitteln für fleischbasierte Optionen, ohne pflanzliche Alternativen in Betracht zu ziehen. Umfrageexperiment: Die Ergebnisse zeigen, dass die Umweltbotschaft die Wahl eines pflanzlichen Abendessens auf zwei Wegen deutlich erhöhte. Bei Verbrauchern, die sich für ein pflanzliches Mittagessen entschieden, verstärkte die Botschaft ihre #Umweltidentität, was zu einer stärkeren Wahl eines pflanzlichen Abendessens führte. Bei denjenigen, die sich für ein fleischbasiertes Mittagessen entschieden, löste die Botschaft #kognitiveDissonanz aus, was die Wahrscheinlichkeit erhöhte, dass sie sich für pflanzliche Abendessenoptionen entschieden.
Goal-framing theory and sustainable food choices: Leveraging #spillover to activate #moral goals - #govegan #Ernährung
sciencedirect.com/science/arti

Characterization of Avian #Influenza Viruses Detected in #Kenyan Live #Bird #Markets & Wild Bird Habitats Reveal Genetically Diverse #Subtypes & High Proportion of #H9N2, 2018–20, Viruses: mdpi.com/1999-4915/16/9/1417

Although HPAI H5N8 was not detected in this survey, these results highlight potential for introduction & establishment of highly pathogenic avian influenza viruses in #poultry populations and associated #risk of #spillover to human populations.

MDPICharacterization of Avian Influenza Viruses Detected in Kenyan Live Bird Markets and Wild Bird Habitats Reveal Genetically Diverse Subtypes and High Proportion of A(H9N2), 2018–2020Following the detection of highly pathogenic avian influenza (HPAI) virus in countries bordering Kenya to the west, we conducted surveillance among domestic and wild birds along the shores of Lake Victoria. In addition, between 2018 and 2020, we conducted surveillance among poultry and poultry workers in live bird markets and among wild migratory birds in various lakes that are resting sites during migration to assess introduction and circulation of avian influenza viruses in these populations. We tested 7464 specimens (oropharyngeal (OP) and cloacal specimens) from poultry and 6531 fresh fecal specimens from wild birds for influenza A viruses by real-time RT-PCR. Influenza was detected in 3.9% (n = 292) of specimens collected from poultry and 0.2% (n = 10) of fecal specimens from wild birds. On hemagglutinin subtyping, most of the influenza A positives from poultry (274/292, 93.8%) were H9. Of 34 H9 specimens randomly selected for further subtyping, all were H9N2. On phylogenetic analysis, these viruses were genetically similar to other H9 viruses detected in East Africa. Only two of the ten influenza A-positive specimens from the wild bird fecal specimens were successfully subtyped; sequencing analysis of one specimen collected in 2018 was identified as a low-pathogenicity avian influenza H5N2 virus of the Eurasian lineage, and the second specimen, collected in 2020, was subtyped as H11. A total of 18 OP and nasal specimens from poultry workers with acute respiratory illness (12%) were collected; none were positive for influenza A virus. We observed significant circulation of H9N2 influenza viruses in poultry in live bird markets in Kenya. During the same period, low-pathogenic H5N2 virus was detected in a fecal specimen collected in a site hosting a variety of migratory and resident birds. Although HPAI H5N8 was not detected in this survey, these results highlight the potential for the introduction and establishment of highly pathogenic avian influenza viruses in poultry populations and the associated risk of spillover to human populations.

Multiple #transatlantic #incursions of #HPAI clade 2.3.4.4b A(#H5N5) virus into North #America and #spillover to #mammals, Cell Rep.: cell.com/cell-reports/fulltext

#Seabirds likely enabled multiple incursions of A(H5N5) virus from #Europe to #Canada. Some A(H5N5) viruses possessed the mammalian #adaptation #marker #PB2-E627K. A(H5N5) viruses demonstrated rapid 100% #mortality and some transmission in #ferrets. A(H5N5) viruses preferred avian virus receptors and are sensitive to NA #inhibitors.

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"HPAI #H5N1 influenza viruses do not transmit efficiently among #mammals. Moreover, influenza A viruses have rarely been detected in #cattle. Thus, the current #outbreak of HPAI H5N1 influenza viruses in dairy cows and the #spillover into other mammalian species may have profound consequences for #PublicHealth and the dairy industry. [...]

Recently, mammal-to-mammal transmission may have occurred during outbreaks of HPAI H5N1 viruses in mink in Spain and sea mammals [in] South America" [5]

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Recent work on "pathogenicity and transmissibility of bovine H5N1 influenza virus" [5]:

"Highly pathogenic #H5N1 #AvianInfluenza (HPAI H5N1) viruses occasionally infect, but typically do not transmit, in #mammals. In the Spring of 2024, an unprecedented outbreak of HPAI H5N1 in #bovine herds occurred in the US, with virus spread within and between herds, infections in #poultry and #cats, and #spillover into humans, collectively indicating an increased public health risk" [5]

Continued thread

''Beyond the proximal drivers of outbreaks and potential interventions though, there is a need to confront an uncomfortable truth that the US H5N1 outbreak once again raises. #Spillover of #zoonoses into human populations stems ultimately from our ways of life and how they shape the human–animal interface. Our #diets, our intensive #farming practices, our livelihoods, our behaviours, and our cultures. ''

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Again [3]: "a significant portion of the world’s population will experience [...] prolonged exposures to uncompensable #ExtremeMoistHeat.

Humans will struggle to adapt to these conditions in a warmer world as they will present widespread challenges across many aspects of food–energy–water security, human health, and economic development including in the world’s most populous and most vulnerable regions" [3]

In addition, "the magnitude to which #spillover effects take place is unknown" [3]

Avian #Influenza #outbreaks: #Human #infection #risks for #beach users - #OneHealth concern and environmental #surveillance implications, Sci Total Environ.: sciencedirect.com/science/arti

The likelihood of avian influenza spreading to beachgoers is minimal. Unprotected contact with sick and dead #animals should be avoided.
Influenza viruses adapt to environments via mutations and reassortment.
#Spillover events raise genomic mutation risk, boosting pandemic potential.

#Outbreaks of #H5N1 High Pathogenicity Avian #Influenza in #SouthAfrica in 2023 Were Caused by Two Distinct Sub-#Genotypes of Clade 2.3.4.4b Viruses, Viruses: mdpi.com/1999-4915/16/6/896

South African clade 2.3.4.4b H5N1 viruses had comparatively fewer #markers of #virulence and #pathogenicity compared to European strains, a possible reason why no #spillover to #mammals has occurred here yet.

MDPIOutbreaks of H5N1 High Pathogenicity Avian Influenza in South Africa in 2023 Were Caused by Two Distinct Sub-Genotypes of Clade 2.3.4.4b VirusesIn 2023, South Africa continued to experience sporadic cases of clade 2.3.4.4b H5N1 high-pathogenicity avian influenza (HPAI) in coastal seabirds and poultry. Active environmental surveillance determined that H5Nx, H7Nx, H9Nx, H11Nx, H6N2, and H12N2, amongst other unidentified subtypes, circulated in wild birds and ostriches in 2023, but that H5Nx was predominant. Genome sequencing and phylogenetic analysis of confirmed H5N1 HPAI cases determined that only two of the fifteen sub-genotypes that circulated in South Africa in 2021–2022 still persisted in 2023. Sub-genotype SA13 remained restricted to coastal seabirds, with accelerated mutations observed in the neuraminidase protein. SA15 caused the chicken outbreaks, but outbreaks in the Paardeberg and George areas, in the Western Cape province, and the Camperdown region of the KwaZulu-Natal province were unrelated to each other, implicating wild birds as the source. All SA15 viruses contained a truncation in the PB1-F2 gene, but in the Western Cape SA15 chicken viruses, PA-X was putatively expressed as a novel isoform with eight additional amino acids. South African clade 2.3.4.4b H5N1 viruses had comparatively fewer markers of virulence and pathogenicity compared to European strains, a possible reason why no spillover to mammals has occurred here yet.

International scientists call for greater conservation to reduce risk of future pandemics.

"To effectively prevent pandemics, we must recognize 2 keys points: 1st that pandemics almost always start with a microbe infecting a wild animal in a natural environment and 2nd that human caused land use change often triggers the events- whether through wildlife trade or other distal activities- that facilitate spillover of microbes from wild animals to humans"

cidrap.umn.edu/misc-emerging-t

www.cidrap.umn.eduPandemic-prevention plan stresses conservation of animal habitats and their food suppliesHuman-caused land-use change often triggers the events that facilitate spillover of pathogens from wild animals to people.