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#freeenergy

2 posts2 participants0 posts today
Public
JdeB

463 #ClimateSolutions #FreeEnergy

Minus your investments your household could have free energy !
Think about it: no more gasbills for your home or your car.
#StopBurnigThings and #Electrify.
And it's about #Autonomy not about 'earning money' with somekind of return from your energy supplier. You yourself are the supplier.
Make sure you make all your energy use is electrical. #Electrfy
Heating: heatpumps but also Infra Red panels.
Car: electric [make sure that it's a two way model, so you ca really use the battery]
Install more than enough solar panels [more than you would need now; you've got more electrifying to do]
Install plenty battery capacity.
Remember: to much solar is a waste but it doesn't cost you money.
And about those investments, yes they are big but remember that most of the equipment you install has a garantee of 20 yrs or more. Now any calculation will have a break even at some 10yrs or less. Remaining is 10 or more years of FREE ENERGY.

disclaimer: everybody should make their own calculations based on their own situation and make their own decisions ! But the rule-of-thumb will stand.

You can save the world without #BigOil !

"Solar goes EXPONENTIAL - surpasses even Tony Seba's projections" [13:51 min]
by The Electric Viking

youtube.com/watch?v=naIN4IlJk8

Quote by TEV
"Sep 21, 2024
Solar goes EXPONENTIAL - surpasses even Tony Seba's projections"

#TakeCareForLife #TakeCareForEarth
#StopBurnigThings #StopEcoside

Public
El Perro Negro

Our trusty sun/solar oven at work early this morning. A dhal curry is gently going to cook for hours during the day.

We bought this oven some 15+ years ago and its given excellent service. Anybody with some DIY skills could make this (I have none!). Its relatively simple, a black box with a parabolic aluminium shield. A very efficient, free energy resource.

A solar oven with a parabolic shield sits on a table surrounded by chairs. In the background some olive trees.
#selfsuffiency#freeenergy#sun
Public *
Kudra :maybe_verified:

It's funny, a few years ago I was telling people that the cost of electricity would eventually approach zero, as solar panel efficiency improved, but I honestly think people thought I was mad. Talking about "free energy" still makes people think you must have a screw loose. But if you don't think in capitalist terms, and try to imagine a world where technology and traditional lifestyles in which humans barely worked to survive (hunter gatherers didn't have to work too many hours to hunt and gather enough food to live) can coexist, a better world where we have our needs met and DON'T destroy our environment is actually possible.

#sustainability#solar#ongrid
Public
Martin Vögele

First preprint about my work at Schrödinger:

We show how to predict ligand efficacy via absolute binding free energy perturbation on different receptor conformations — confirming and utilizing the principle that the functional response of a receptor is mainly determined by the thermodynamics of ligand binding.

chemrxiv.org/engage/chemrxiv/a

ChemRxivIs the functional response of a receptor determined by the thermodynamics of ligand binding?Although strong binding to the target protein is a prerequisite, it is not enough to be an effective drug. To produce a particular functional response, drugs need to regulate the targets’ signal transduction pathways, either blocking the proteins’ functions or modulating their activities by changing the conformational equilibrium. The routinely calculated binding free energy of a compound to its target is a good predictor of affinity but may not always predict efficacy. While the time scales for the protein conformational changes are prohibitively long to be routinely modeled via physics-based simulations, thermodynamic principles suggest that binding free energies of the ligands with different receptor conformations may infer their efficacy if the functional response of the receptor is determined by thermodynamics. However, while this hypothesis was proposed in the past, it has not been thoroughly validated and is seldom used in practice for ligand efficacy prediction. We present an actionable protocol and a comprehensive validation study to show that binding thermodynamics provides indeed a strong predictor for the efficacy of a ligand. We apply the absolute-binding free energy perturbation (ABFEP) method to ligands bound to active and inactive states of eight G protein–coupled receptors (GPCRs) and a nuclear receptor. By comparing the resulting binding free energies, we can determine with a very high accuracy whether a ligand acts as an agonist or an antagonist. We find that carefully designed restraints are often necessary to efficiently model the corresponding conformational ensembles for each state and provide a procedure for setting up these restraints. Our method achieves excellent performance in classifying ligands as agonists or antagonists across the various investigated receptors, all of which are important drug targets.
#FEP#FreeEnergy#LigandEfficacy
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